30DEC

Libyan International Conference for Health Sciences

The First Libyan International Conference for Health Sciences (2024): Open University, Tripoli, Libya
Mediterranean Journal of Pharmacy and Pharmaceutical Sciences
https://ppj.org.ly/article/673a46a6a953950452504973

Mediterranean Journal of Pharmacy and Pharmaceutical Sciences

Original article

Comparative assessment of Solanum melongena (Eggplant) against multi-drug-resistant Staphylococcus aureus and Pseudomonas aeruginosa

Ijeoma N. Ebenebe, Chinenye H. Nedum, Ugochukwu M. Okezie, Nneka R. Egbuna, Chidinma C. Obasi, Miriam-Goodness U. Nwaneri

Mediterr J Pharm Pharm Sci, Ahead of Print, 2024
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Abstract

Solanum melongena (Eggplant) is a medicinal plant belonging to the family Solanaceae. This study aimed to perform a comparative assessment of the methanol extracts of the fruit and the leaf of Solanum melongena against multi-drug-resistant Staphylococcus aureus and Pseudomonas aeruginosa. The crude extracts were obtained from the leaves and fruits of the plant using methanol. The plant extracts were tested for the presence of various phytochemical constituents qualitatively. The antibacterial assay and minimum inhibitory concentration for the crude extracts were carried out using the agar well diffusion and agar dilution methods, respectively. Phytochemical analysis of methanol extracts of Solanum melongena revealed the presence of various phytoconstituents. Antibacterial assay of methanol extracts of Staphylococcus melongena against multi-drug-resistant Staphylococcus aureus isolates with ciprofloxacin as a reference control revealed inhibition zone diameter ranging from 04.0±0.0 to 11.0±0.0 mm; in contrast that of multi-drug-resistant Pseudomonas aeruginosa isolates revealed inhibition zone diameter, with ciprofloxacin showing no inhibition. The minimum inhibitory concentration of the methanol extracts on Pseudomonas aeruginosa isolates ranges from 25.0 to 50.0 mg/ml and 25.0->50.0 mg/ml, respectively, in comparison, the minimum inhibitory concentration of the methanol extracts on Staphylococcus aureus isolates ranges from 6.25 to 50.0 mg/ml and 6.25->50.0 mg/ml respectively. Thus, the fruit extract had better activity against test multi-drug-resistant Pseudomonas aeruginosa and Staphylococcus aureus than the leaf extract of Solanum melongena.

Keywords

Minimum inhibitory concentration, multi-drug resistant, vancomycin-ofloxacin resistant

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Submitted date:
10/18/2024

Reviewed date:
11/13/2024

Accepted date:
11/17/2024

Publication date:
11/17/2024

673a46a6a953950452504973 medjpps Articles
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