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Mediterranean Journal of Pharmacy and Pharmaceutical Sciences
https://ppj.org.ly/article/6a03ba54a95395260469b5c6

Mediterranean Journal of Pharmacy and Pharmaceutical Sciences

Short communication Medicinal chemistry

Design of pyrrolidine-2,5-dione Schiff’s base derivatives as GABAA inhibitors for antiepileptic activity

Balsam A. Abodabous, Suaad M. Abuskhuna, Nisreen H. Meiqal , Omran N.R. Fhaid

Mediterr J Pharm Pharm Sci, Ahead of Print, 2026
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Abstract

Succinimide derivatives are an essential class of compounds with diverse pharmacological applications. Different derivatives of succinimide as Schiff’s base were designed for good inhibitory activity against the human GABAA receptor. Compounds that inhibit GABAA are effective as anti-epileptic agents. Virtual screening methods such as ADMET properties and Molecular docking were used. ADMET properties and drug likeliness of all investigated compounds were predicted by Swiss ADMET software. A higher binding affinity and interactions have been observed with the designed compounds compared to the standard compounds (Phenobarbital and Flumazenil).

Keywords

Anti-epileptic agents, GABAA receptor, molecular docking, Schiff`s base 

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Submitted date:
03/29/2026

Reviewed date:
05/11/2026

Accepted date:
05/13/2026

Publication date:
05/12/2026

6a03ba54a95395260469b5c6 medjpps Articles
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