30DEC

Libyan International Conference for Health Sciences

The First Libyan International Conference for Health Sciences (2024): Open University, Tripoli, Libya
Mediterranean Journal of Pharmacy and Pharmaceutical Sciences
https://ppj.org.ly/article/doi/10.5281/zenodo.10050456

Mediterranean Journal of Pharmacy and Pharmaceutical Sciences

Short communication

Trace elements in blood of leukemia patients

Asma O. Jebril, Suaad M. Abuskhuna, Amina M. Bishr, Othman A. Abdulrhman, Sara A. Almabrok, Esra K. Kshad, Abdarahman A. Alaan, Imad M. Aghila

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Abstract

Trace elements are minerals present in living tissues in small amounts. Some of them are known to be nutritionally essential, others may be essential, and the remainder are considered to be nonessential. Trace elements such as zinc, copper, selenium, iron, chromium and, others are essential elements for growth and body health. They form an integral part of many enzymes and bioactive centers that are responsible for biochemical reactions such as metabolism, protein and, DNA synthesis. They are said to contribute to the development of cancer based on epidemiologic evidence. The blood level of trace elements in the human body is affected by cancer and drug treatment. The low trace elements level is a sign of leukemia patients, where cancer cells consume body nutrients and essential elements for growth. The Libyan patients were divided into four age groups and were either newly or old diagnosed with leukemia, including patients with acute leukocyte leukemia, acute myeloid leukemia, chronic myelogenous leukemia, and aplastic anemia. The samples were tested for direct aspiration onto inductively coupled plasma spectrometry at specific wave lengths. The findings showed the blood level of trace elements in leukemia patients is lower than in the healthy individuals. A negative correlation between copper and zinc levels in leukemia patients was found. The copper level increases in leukemia patients as they get older.

Keywords

Age, cancer, leukemia, Libya, trace element level

References

  1. Classen HG, Gröber U, Löw D, Schmidt J, Stracke H (2011) Zinc deficiency. Symptoms, causes, diagnosis and therapy. Medizinische Monatsschrift fur Pharmazeuten. 34 (3): 87-95. PMID: 21736013.
  2. Sandstead HH (1994) Understanding zinc: recent observations and interpretations. The Journal of Laboratory and Clinical Medicine. 124 (3): 322-327. PMID: 8083574.
  3. McCarthy TJ, Zeelie JJ, Krause DJ (1992) The antimicrobial action of zinc ion/antioxidant combinations. Journal of Clinical Pharmacology and Therapeutics. 17 (1): 51-54. doi: 10.1111/j.1365-2710.1992.tb01265.x
  4. Solomons NW (1998) Mild human zinc deficiency produces an imbalance between cell-mediated and humoral immunity. Nutrition Reviews. 56 (1): 27-28. doi: 10.1111/j.1753-4887.1998.tb01656.x
  5. Zundahl S (1998) Chemical Principles: Study guide. 3rd ed, Houghton Mifflin College, New York. ISBN-13: ‎ 978-0395839966.
  6. Prasad AS (1995) Zinc: an overview. Nutrition. 11 (1S): 93-99. PMID: 7749260.
  7. Fraga CG, Oteiza PI (2002) Iron toxicity and antioxidant nutrients. Toxicology. 180 (1): 23-32. doi: 10.1016/s0300-483x(02)00379-7
  8. Araya M, Pizarro F, Olivares M, Arredondo M, Gonzalez M, Mendez M (2006) Understanding copper homeostasis in humans and copper effects on health. Biological Research. 39 (1): 183-187. doi: 10.4067/s0716-97602006000 100020
  9. Rakel D (2022) Integrative medicine. Saunders Elsevier, 5th ed. ISBN: 9780323777285
  10. Kanumakala S, Boneh A, Zacharin M (2002) Pamidronate treatment improves bone mineral density in children with Menkes disease. Journal of Inherited Metabolic Disease. 25 (5): 391-398. doi: 10.1023/a:1020103901969
  11. Das KK, Gupta AD, Dhundasi SA, Patil AM, Das SN, Ambeker JG (2006) Effect of L-ascorbic acid on nickel-induced alterations in serum lipid profiles and liver histopathology of rats. Journal of Basic and Clinical Physiology and Pharmacology. 17 (1): 29-44. doi: 10.1515/jbcpp.2006.17.1.29
  12. Elin RJ (2010) Assessment of magnesium status for diagnosis and therapy. Magnesium Research. 23 (4): S194-S198. doi: 10.1684/mrh.2010.0213
  13. Swaminathan R (2003) Magnesium metabolism and its disorders. The Clinical Biochemist Review. 24 (2): 47-66. PMID: 18568054.
  14. Saris NE, Mervaala E, Karppanen H, Khawaja JA, Lewenstam A (2000) Magnesium. An update on physiological, clinical and analytical aspects. Clinica Chimica Acta. 294: 1-26. doi: 10.1016/s0009-8981(99)00258-2
  15. Aikawa JK (2019) Magnesium: Its biological significance. Boca Raton, FL: CRC Press, 1st ed. doi.org/10.1201/ 9780429276101
  16. Geiger H, Wanner C (2012) Magnesium in disease. Clinical Kidney Journal. 5 (S1): i25-i38. doi: 10.1093/ ndtplus/sfr165
  17. Wacker WEC (1980) Magnesium and Man. Harvard University Press. E-edition. ISBN: 9780674366374.
  18. Arthur JR, Beckett GJ (1994) New metabolic roles for Selenium. The Proceedings for Nutrition Society. 53 (3): 615-624. doi: 10.1079/pns19940070
  19. Whanger PD (1992) Selenium in the treatment of heavy metal poisoning and chemical carcinogenesis. Journal of Trace Elements and Electrolytes in Health and Disease. 6 (4): 209-221. PMID: 1304229.
  20. Subramanyam D, Subbaiah KV, Rajendra W, Lokanatha V (2013) Serum selenium concentration and antioxidant activity in cervical cancer patients before and after treatment. Experimental Oncology. 35 (2): 97-100. PMID: 23828383.
  21. Thomson CD (2004) Assessment of requirements for selenium and adequacy of selenium status: a review. European Journal of Clinical Nutrition. 58 (3): 391-402. doi: 10.1038/sj.ejcn.1601800
  22. McConnell KP, Cooper BJ (1950) Distribution of selenium in serum proteins and red blood cells after subcutaneous injection of sodium selenite containing radioselenium. Journal of Biological Chemistry. 183 (2): 459-466. Accession: 024506441.
  23. De Rosa V, Erkekoğlu P, Forestier A, Favier A, Hincal F, Diamond AM, Douk T, Rachidi W (2012) Low doses of selenium specifically stimulate the repair of Oxidative DNA damage in LNCaP prostate cancer cells. Free Radical Research. 46 (2): 105-116. doi: 10.3109/10715762.2011.647009
  24. Akanni EO, Onuegbu AJ, Adebayo TO, Eegunranti BA, Oduola T (2013) Assessment of some selected trace metals in chronic myeloid leukemia patients in a Tertiary Health Facility in South West Nigeria. Asian Journal of Medical Science. 5 (4): 71-75. doi: 10.19026/ajms.5.5487
  25. Azin F, Raie RM, Mahmoudi MM (1998) Correlation between the levels of certain carcinogenic and anticarcinogenic trace elements and esophageal cancer in northern Iran. Ecotoxicology and Environmental Safety. 39 (3): 179-184. doi: 10.1006/eesa.1997.1601
  26. Wesdorp RI, Krause R, Von Meyenfeldt MF (1983) Cancer cachexia and its nutritional implications. The British Journal of Surgery. 70 (6): 352-355. doi: 10.1002/bjs.1800700615
  27. Tariq SR, Ejaz A, Mahmud T, Tariq AR (2016) Distributive variability of selected trace elements in the blood samples of leukemia patients. Journal of Heavy Metal Toxicity and Diseases. 1 (5): 1-10. doi: 10.21767/2473-6457. 100005
  28. Nemoto K, Kondo Y, Himeno S, Suzuki Y, Hara S, Akimoto M, Imura N (2000) Modulation of telomerase activity by zinc in human prostatic and renal cancer cells. Biochemical Pharmacology. 59 (4): 401-405. doi: 10.1016/s0006-2952(99)00334-2
  29. Hasan A (2017) Effect of Chemotherapy on Zn, Fe, Mg, Pb, Ca and Se in the serum. Modern Chemistry and Applications. 5 (1): 212. doi: 10.4172/2329-6798.1000212
  30. Bonham M, O'Conner JM, Hannigan BM, Strain JJ (2002) The immune system as a physiological indicator of marginal copper status. The British Journal of Nutrition. 87 (5): 393-403. doi: 10.1079/BJNBJN2002558
  31. Widman L, Wester PO, Stegmayr BK, Wirell M (1993) The dose-dependent reduction in blood pressure through administration of magnesium a double-blind placebo controlled cross-over study. American Journal of Hypertension 6 (1): 41-45. doi: 10.1093/ajh/6.1.41
  32. Simonoff M, Sergeant C, Garnier N, Moretto P, Llabedor Y, Simonoff G, Conri C (1992) Antioxidant status (selenium, vitamins A and E) and aging, EXS. 62: 368-397. doi: 10.1007/978-3-0348-7460-1_37
  33. Çaglayan O, Aydog YŞ (1997) Serum zinc and copper levels in rheumatoid arthritis. Journal of Islamic Academy of Sciences. 10 (1): 19-24. doi: Nil.
  34. Arnbjörnsson E, Abdulla M (1986) Correlation between copper, zinc and ceruloplasmin in plasma of patients admitted for acote abdomen. Acta Pharmacologica et Toxicologica 59 (S7): 180-183. doi: 10.1111/j.1600-0773. 1986.tb02739.x

Submitted date:
10/06/2023

Reviewed date:
10/26/2023

Accepted date:
10/28/2023

Publication date:
10/28/2023

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