In this article, a systematic flow of contents was provided about the synthesis of Atovaquone 1a on a critical examination of the prior arts. Several patents and study articles were published, disclosing different synthetic methods for the preparation of Atovaquone 1a at various scales. Based on the starting materials used, there are a few one-step, two-step and multi-step synthetic routes were reported with varied yields. In this work, we have put in our sincere effort to collect all the synthetic routes of Atovaquone 1a in detail with distinct and elaborate reaction schemes for better and collective process clarity. From this review, global researchers will get a platform to re-design or re-work the synthetic approach of Atovaquone 1a with better atom economy and purity. In addition, the drug commercialization angle could also be looked at during the design stage itself alongside green chemistry concepts. We have done a chronic analysis of study articles to highlight the commercial feasibility of the disclosed synthetic methods. A special emphasis was given to the synthetic routes with process development initiatives towards, recovery/reuse of costly starting materials/ reagents/solvents and their feasibility for large-scale manufacturing of drug Atovaquone 1a.