30DEC

Libyan International Conference for Health Sciences

The First Libyan International Conference for Health Sciences (2024): Open University, Tripoli, Libya
Mediterranean Journal of Pharmacy and Pharmaceutical Sciences
https://ppj.org.ly/article/doi/10.5281/zenodo.10389843

Mediterranean Journal of Pharmacy and Pharmaceutical Sciences

Short communication

A comparative evaluation of furosemide tablets marketed in Libya

Shahrazad A. Eteer, Jamal A. Elbakay, Nesrine A. Almashai, Hayam A. Maree, Safa S. Elgadi, Tariq K. Almog

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Abstract

Furosemide is a widely potent diuretic drug used in the management of edema and hypertension. Various brands of furosemide are available in the Libyan market and should be subjected to different quality control tests to assess their pharmaceutical equivalence. This study aimed to assess and compare the quality and the pharmaceutical equivalence of some generic brands of furosemide 40 mg tablets marketed in Libya. The pharmaceutical quality of four brands of furosemide tablets was investigated using official and unofficial compendia standards including uniformity of weight, friability, thickness, hardness, drug content and dissolution rate. The results obtained showed acceptable external features as well as the thickness, diameter and uniformity of weight for all the furosemide tablets. The tested brands complied with the official specifications of friability, hardness and drug content. In conclusion, all four brands can be considered as bioequivalence and thus can be pharmaceutically substituted in clinical practice. 

Keywords

Furosemide, pharmaceutical equivalence, quality control evaluation

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Submitted date:
11/20/2023

Reviewed date:
12/10/2023

Accepted date:
12/14/2023

Publication date:
07/20/2024

669c0d35a9539520e32baa85 medjpps Articles
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