30DEC

Libyan International Conference for Health Sciences

The First Libyan International Conference for Health Sciences (2024): Open University, Tripoli, Libya
Mediterranean Journal of Pharmacy and Pharmaceutical Sciences
https://ppj.org.ly/article/doi/10.5281/zenodo.11173840

Mediterranean Journal of Pharmacy and Pharmaceutical Sciences

Original article

Effects of jatropha curcas root extracts on the metabolic profile of mature female rats

Ale Ayotunde Oladunni, Odesanmi Omolola Selina, Magbagbeola Olubunmi Abiola

http://dx.doi.org/10.5281/zenodo.11173840 Mediterr J Pharm Pharm Sci, vol.4, n2, p.23-29, 2024
PDF
PDF
Downloads: 0
Views: 210

Abstract

Extracts from Jatropha curcas, a tropical shrub, serve as multi-purpose treatments in folk medicine. Previous studies have shown conflicting reports of the metabolic effects of the extract of this plant. This study assessed the effects of Jatropha curcas root extracts on metabolic parameters of female Wistar rats, including body weight, glycemic index, and lipid profile. The root extracts of Jatropha curcas in water and 80.0% ethanol were prepared using the Soxhlet extraction method. Four groups of mature rats (groups A-D) were administered varying doses of water or ethanol extracts once daily for 15 days. Another group (group E) served as a control and received no extract. After stopping extract administration, the rats were fasted for 18 hrs and sacrificed. A venous blood sample was collected from each group for analysis of lipid and glycemic profiles using spectrophotometry. Statistical analysis was performed and the value with P < 0.05 was regarded as significant. No significant difference was observed in the overall body weights of the rats of any group before and after the treatment. Furthermore, the rats that were administered with the root extracts (either water or ethanol) exhibited higher levels of fasting blood glucose and serum lipids compared to the rats in the control group. In conclusion, the root extracts of Jatropha curcas predispose the rats to hyperlipidemia action and hyperglycemia action.

Keywords

J. curcas, metabolic effects, hyperlipidemia, hyperglycemia

References

  1. Makkar HPS, Becker K (2009) Jatropha curcas, a promising crop for the generation of biodiesel and value-added coproducts. European Journal of Lipid Science and Technology. 111 (8): 773-787. doi: 10.1002/ejlt. 200800244
  2. Ishii Y, Takeuchi R, Tokida K (1987) Trans-esterified curcas oil as a farm diesel engine fuel. In: Proceedings of the international symposium on agriculture mechanization and international cooperation in the high technology era. University of Tokyo, Tokyo, Japan.
  3. Munch E, Kiefer J (1989) Purging nut (J. curcas L) Multi-use plant as a source of fuel in the future. Schriftenreihe der GTZ. 209: 1-32. doi: Nil.
  4. Jongschaap R, Corre WJ, Bindraban PS, Brandenburg WA (2007) Claims and facts on Jatropha curcas L. Plant Research International. B.V, 1-42. Wageningen Stichting Het Groene Woudt, Laren. doi: Nil.
  5. Johnson M, Olufunmilayo LA, Adegboyega CC, Adetayo OM (2014) Evaluation of antidiabetic and the effect of methanolic leaf extract of Jatropha curcas on some biochemical parameters in alloxan-induced diabetic male albino rats. European Journal of Medicinal Plants. 4 (12): 1501-1512. doi: 10.9734/EJMP/2014/12500
  6. Shukla A, Singh SP, Tiwari S (2015) Transformation of toxic potential of Jatropha curcas (Ratanjyot) into protein source: A mini-review. Journal of Advanced Veterinary and Animal Research. 2 (2): 89-94. doi: 10.5455/javar.2015.b82
  7. Gadekar KP (2006) Vegetative propagation of Jatropha curcas, Karanji and Mahua by stem cuttings, grafting, budding and air-layering, M.Sc. Forestry Thesis, Department of Forestry, Indra Gandhi Agricultural University, Raipur. New Delhi-110 012, India.
  8. Solsoloy AD, Solsoloy TS (1997) Pesticidal efficacy of formulated J. curcas oil on pests of selected field crops. In: Gubitz, GM, Mittelbach M, Trabi M (Ed.), Biofuels and Industrial Products from Jatropha curcas. DBV Graz. 25: 216-226.
  9. Thomas OO (1989) Re-examination of the antimicrobial activities of Xylopia aethiopica, Carica papaya, Ocimum gratissimum, and Jatropha curcas. Fitoterapia. 60 (2): 147-155. doi: Nil.
  10. Burkill HM (1994) The useful plants of west tropical Africa. Volume 2, Royal Botanical Gardens, Kew Publishing, UK. ISBN: 9780947643560.
  11. Duke JA (1985) Medicinal plants (Letter). Science. 229 (4718):1036-1038. PMID: 4035343.
  12. Igoli JO, Ogaji OG, Tor-Anyiin TA, Igoli NP (2005) Traditional medicine practice amongst the Igede people of Nigeria. African Journal of Traditional, Complementary and Alternative Medicines. 2 (2): 134-152. doi: 10.4314/ajtcam.v2i2.31112
  13. Goonasekera MM, Gunawardana VK, Jayasena K, Mohammed SG, Balasubramaniam S (1995) Pregnancy terminating effect of Jatropha curcas in rats. Journal of Ethnopharmacology. 47 (3): 117-123. doi: 10.1016/ 0378-8741(95)01263-D
  14. Achten WMJ, Verchot L, Franken YJ, Mathijs E (2008) Jatropha biodiesel production and use (a review). Biomass and Bioenergy. 32 (12): 1063-1084. doi: 10.1016/j.biombioe.2008.03.003
  15. Aldodo RA, Muhammad NO, Balogun EA (2013) Effects of aqueous root extract of Jatropha curcas on hyperglycaemic and haematological indices in alloxan-induced diabetic rats. Fountain Journal of Natural and Applied Sciences. 2 (1): 52-58. doi: 10.53704/fujnas.v2i1.39
  16. Shikov AN, Mikhailovskaya IY, Narkevich IA, Flisyuk EV, Pozharitskaya ON (2022) Methods of extraction of medicinal plants. In: Evidence-Based Validation of Herbal Medicine, Ed: Mukherjee PK (2nd Ed), Elsevier. 771-796. ISBN 9780323855426. doi: 10.1016/B978-0-323-85542-6.00029-9
  17. Ahirrao RA, Pawari SP, Borse LB, Borse SL, Desai SG (2009) Anthelmintic activity of leaves of Jatropha curcas linn and Vitex negundo linn. Pharmacologyonline. 1: 276-279. Corpus ID: 86354840.
  18. Lott JA, Turner K (1975) Evaluation of Trinder’s glucose oxidase method for measuring glucose in serum and urine. Clinical Chemistry. 21 (12): 1754-1760. PMID: 1237363.
  19. Abell LL, Levy BB, Brodie BB, Kendall FE (1952) Simplified methods for the estimation of the total cholesterol in serum and demonstration of specificity. Journal of Biological Chemistry. 195 (1): 357-366. doi: 10.1016/ S0021-9258(19)50907-3
  20. Bucolo G, David H (1973) Quantitative determination of serum triglyceride by the use of enzymes. Clinical Chemistry. 19 (5): 476-482. PMID: 4703655.
  21. Lopez-Virella ML, Stone P, Ellis S, Colwell JA (1977) Cholesterol determination in high density Lipoprotein separated by three different methods. Clinical Chemistry. 23 (5): 882-884. PMID: 192488.
  22. Friedwald WT, Levy RI, Fredrickson DS (1972) Estimation of the concentration of low-density lipoprotein cholesterol in plasma, without the serum of the preparative ultracentrifuge. Clinical Chemistry. 18 (6): 499-502. PMID: 433738.
  23. Morton JF, Thomas HQ (1981) Anti-malarial activity of Jatropha curcas leaf extract. India Herbal Pharmacopoeia. Public Regional Research Laboratory. 20: 53-57. doi: Nil.
  24. Prasad DMR, Izam A, Khan MMR (2012) Jatropha curcas: Plant of medical benefits. Journal of Medicinal Plants Research. 6: 2691-2699. doi: 10.5897/JMPR10.977
  25. Sofowora A (1993) Medicinal plants and traditional medicine in Africa. (1993) 2nd Ed., Spectrum Books Ltd., Ibadan, Nigeria. ISBN-13: 9782462195.
  26. Oskoueian E, Abdullah N, Saad WZ, Omar AR, Ahmad S, Kuan WB, Zolkifli NA, Hendra R, Ho YW (2011) Antioxidant, anti-inflammatory and anticancer activities of methanolic extracts from Jatropha curcas Linn. Journal of Medicinal Plants Research. 5 (1): 49-57. doi: 10.5897/JMPR.9000229
  27. Mujumdar AM, Misar AV, Salaskar MV, Anuradha U (2001) Anti-diarrheal effect of an isolated fraction (JC) of Jatropha curcas roots in mice. Journal of Natural Remedies. 1 (2): 89-93. doi: 10.18311/jnr/2001/14
  28. Duke JA, Wain KK (1981) Medicinal plants of the world. Computer index with more than 85,000 entries. Volume 3. Plants Genetics, Germplasm Institute, Agriculture Research Service, Beltsville, Maryland.
  29. List PH, Horhammer L (1969) Harger's Handbuck Der Pharmaceutischen. 1969. Springer-Verlag, Berlin, Germany. doi: 10.1007/978-3-642-57881-6
  30. Mofijur M, Masjuki HH, Kalam MA, Hazrat MA, Liaquat AM, Shahabuddin M, Varman M (2012) Prospects of biodiesel from Jatropha in Malaysia. Renewable and Sustainable Energy Reviews. (16) 7: 5007-5020. doi: 10.1016/j.rser.2012.05.010
  31. Agaceta LM, Dumag PU, Batolos JA (1981) Studies on the control of snail vectors of fascioliasis; molluscicidal activity of some indigenous plants. NSDB Technology Journal. 7. 38008. 6 (2): 30-34. doi: Nil.
  32. Mitchell J, Rook A (1979) Botanical dermatology. Green Glass Ltd., Vancouver, Canada. ISBN-13: 9780889780477. Pages: 787.
  33. Breyer-Brandwijk MG, Watt JM (1962) The medicinal and poisonous plants of Southern and Eastern Africa. 2nd ed., E & S Livingstone Ltd., Edinburgh, UK. 2 (3): 296-296. doi: 10.1177/030098586500200308
  34. Adam SE (1974) Toxic effects of Jatropha curcas in mice. Toxicology. 2 (1): 67-76. doi: 10.1016/0300-483x (74)90043-2
  35. Abdel Gadir WS, Onsa TO, WEM Ali, EL Badwi S, Adam SEI (2003) Comparative toxicity of Croton macrostachys, Jatropha curca sand Piper abyssinica seeds in Nubian goats. Small Ruminant Research. 48 (1): 61-67. doi: 10.1016/S0921-4488(02)00181-5
  36. Abd-Elhamid HF (2004) Investigation of induced biochemical and histopathological parameters of acetonitrile extract of Jatropha curcas in albino rats. Journal of Egyptian Society of Parasitology. 34 (2): 397-406.
  37. Rakshit KD, Darukeshwara J, Raj KD, Narasimhamurthy K, Saibaba P, Bhagya S (2008) Toxicity studies of detoxified Jatropha meal (Jatropha curcas) in rats. Food and Chemical Toxicology. 46 (12): 3621-3625. doi: 10.1016/j.fct.2008.09.010
  38. Johnson OR, Johnson G, Dwana T, Emmanuel UT (2013) Effect of Jatropha curcas supplemented diet on broilers. Scholars Academic Journal of Biosciences. 1 (6): 329-336. Corpus ID: 13846643.
  39. Ojo RJ, Memudu AE, Akintayo CO, Christropher A, Akpan IS (2012) Effects of pre-induction administration of allium Sativum on some biochemical parameters in alloxan induced diabetic rats. Research Journal of Applied Sciences, Engineering and Technology. 4 (23): 5129-5135. Corpus ID: 67842432.
  40. Liu PS, Lin MK (1997) Biphasic effects of chromium compounds on catecholamine secretion from bovine adrenal medullary cells. Toxicology. 117 (1): 45-53. doi: 10.1016/s0300-483x(96)03552-4
  41. Pushparaj P, Tan CH, Tan BK (2000) Effect of Averrhoa bilimbi leaf extract on blood glucose and lipids in streptozotocin diabetic rats. Journal of Ethnopharmacology. 72 (1-2): 69-76. doi: 10.1016/s0378-8741(00) 00200-2
  42. Sharma SB, Nasir A, Prabhu KM, Murthy PS, Dev G (2003) Hypoglycemic and hypolipidemic effect of ethanolic extract of seeds of Eugenia jambolonain alloxan-induced diabetic rabbits. Journal of Ethnopharmacology. 85 (2-3): 201-206. doi: 10.1016/s0378-8741(02)00366-5
  43. Pepato MT, Baviera AM, Vendramini RC, da Silva Perez MDPM, do CarmoKettelhut I, Brunetti IL (2003) Cissus sicyoides (Princess wine) in the long-term treatment of streptozotocin-diabetic rats. Biotechnology and Applied Biochemistry. 37: 15-20. doi: 10.1042/BA20020065
  44. Brander GC, Pugh DM, Bywater RJ (1991) Veterinary applied pharmacology and therapeutics. 5th Ed., WB Saunders Co., Philadelphia. ISBN-13: 978-0702013669.

Submitted date:
04/21/2024

Reviewed date:
05/05/2024

Accepted date:
05/10/2024

Publication date:
05/10/2024

663dfe1fa953952fbd41c084 medjpps Articles
Links & Downloads
2789-1895 (Electronic) 2958-3101 (Printed)
Mediterr J Pharm Pharm Sci ©2024 All rights reserved.

Mediterr J Pharm Pharm Sci

Share this page
Page Sections