The COVID-19 pandemic has brought to the forefront the critical role of disinfectants and hand sanitizers in preventing the spread of infectious diseases. This study aimed to assess the knowledge, performance, and awareness of individuals regarding the use of these essential hygiene products during the COVID-19 pandemic in Libya, with a focus on the city of Zawia. A structured questionnaire comprising 41 items was utilized to gather data from 200 participants, covering demographics, knowledge about disinfectants and hand sanitizers, performance in utilizing these products, and awareness of their significance. The majority of respondents were female, reflecting a higher awareness and performance level compared to male participants. Social media emerged as a significant source of information, influencing participants' knowledge and practices. Despite a high level of education among participants, significant knowledge gaps were identified, highlighting the need for targeted educational initiatives. The study revealed a marked increase in the use of household disinfectants and hand sanitizers since the onset of the pandemic. However, it also identified high-risk practices, such as mixing chemical products and ingesting alcohol-based hand sanitizers. The findings underscore the importance of ongoing education and awareness campaigns to promote the safe and effective use of disinfectants and hand sanitisers in mitigating the transmission of COVID-19. Addressing these knowledge gaps and promoting proper hygiene practices is crucial for enhancing public health outcomes and reducing the risk of infection in Libya and beyond.