Evaluation of antimicrobial, antioxidant, antidiabetic activities, and acute toxicity of Elephantopus scaber L.
Khin Su Su Han, Kay Thi Win, Myo Thida Chit
http://dx.doi.org/10.5281/zenodo.15365040
Mediterr J Pharm Pharm Sci, Ahead of Print, 2025
Abstract
Elephantopus scaber L., a medicinal plant from Myanmar, was studied to evaluate its biological activity. The activity of antimicrobial assessment showed that ethyl acetate extract exhibited moderate activity in contrast to all six tested organisms. Using the 2,2-Diphenyl-1-picrylhydrazyl (DPPH) free radical scavenging assay with ascorbic acid as standard for antioxidant activity showed that ethyl acetate extract possessed 36.28 μg/mL. The in vivo antidiabetic activity with glipizide, as a standard hypoglycemic agent was employed to determine antidiabetic activity. The data parameter under observation for Elephantopus scaber L. reaches its peak at 135 min, with a 39.0% reduction. No toxic behavior was observed at the limited tested concentrations (2000 mg/kg and 5000 mg/kg) and it suggested a favorable safety profile.
Keywords
DPPH, Elephantopus scaber L., glipizide, medicinal plant, phytochemical properties
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Submitted date:
04/14/2025
Reviewed date:
05/06/2025
Accepted date:
05/08/2025
Publication date:
05/09/2025
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