In some countries, a high percentage of the population relies on traditional plants for treating certain diseases. This study aimed to investigate the effect of G. alypum extract (GAE) and Alhagj marorum extract (AME) on lipid profiles in experimentally induced hypercholesteremic rats and on the blood pressure of experimentally induced hypertensive rats. Male Wistar rats weighing 200-300 g were divided into five groups: group one received a normal diet (negative control), group two received a high lipid diet containing coconut oil (10 g/kg/day), cholesterol (4 g/kg/day) and cholic acid (0.20 g/kg/day) (positive control), group three received a high lipid diet together with clofibrate (50 mg/kg/day), group four received a high lipid diet together with AME (200 mg/kg/day) and group five received GAE (200 mg/kg/day). The experiment continued for two weeks, then the rats were sacrificed and blood samples were collected to estimate of cholesterol, triglycerides, high-density lipoprotein and low-density lipoprotein. To induce hypertension, rats were divided into two groups (n=8 in each group). Group one received normal saline (control) and group two received dexamethasone (0.40 mg/kg, i.p.) for seven consecutive days. Later, the rats were anesthetized using thiopental and the carotid artery was cannulated for recording blood pressure. AME (40 mg/kg) or GAE (40 mg/kg) were injected through a cannula placed into the internal jugular vein at a dose volume of 0.1 ml. Systolic and diastolic blood pressure were measured before and after plant extract administration. The results showed that clofibrate GAE extract and ANE extract significantly decreased cholesterol, triglycerides, low-density lipoprotein and high-density lipoprotein compared to high-lipid diet-treated rats. Data also indicated that administration of GAE or AME extract significantly reduced systolic and diastolic blood pressure in experimentally induced hypertensive rats. In conclusion, GAE and AME have antihyperlipidemic and antihypertensive activities and further investigation is needed to clarify the mechanism of these effects.