30DEC

Libyan International Conference for Health Sciences

The First Libyan International Conference for Health Sciences (2024): Open University, Tripoli, Libya
Mediterranean Journal of Pharmacy and Pharmaceutical Sciences
https://ppj.org.ly/article/doi/10.5281/zenodo.7869374

Mediterranean Journal of Pharmacy and Pharmaceutical Sciences

Original article

Febrile convulsion in Libyan children

Nissren S.S. Majeed, Nahed Abd ALRaziq, Naima I. Abdullah, Safaa S. Muhammed

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Abstract

Febrile convulsions have been defined as any convulsion associated with a fever of more than 38oC without central nervous system infection in a child aged six months to five years. Febrile convulsions can be divided into two groups simple and complex seizures. This study aimed to determine the prevalence of febrile convulsions in Libyan children and to investigate the associated risk factors related to this type of seizure in children. 120 cases of febrile convulsions with one day - 12 years old were collected from April to August 2022. A study was conducted in the Pediatrics Hospital in Bayda City, Libya about the prevalence of febrile convulsions in children, the data collection tool was a self-designed pre-tested validated questionnaire including general information such as age, gender, family history, and admission to the hospital. In addition, data such as body temperature, recurrent convulsion attacks, the condition of hospital admission, discharge status, and the treatment in-hospital and out-hospital. The collected data were analyzed by using descriptive methods. Among the 120 children, the majority of the cases were aged between two years and five years old. The gender prevalence rate in this study was 55.0% in males and 97 of the children were hospitalized due to simple febrile seizure (80.8%), 92 of the cases with no family history of febrile convulsions (75.0%) and respiratory tract infections were the main cause of febrile convulsions. In conclusion, this study indicated that respiratory tract infections are the most common cause of febrile convulsions among Libyan children, however, a large sample study is needed to support this issue in Libya.

Keywords

Children, febrile convulsion, high temperature, seizure 

References

  1. Leung AKC, Hon KL, Leung TNH (2018) Febrile seizures: an overview. Drugs in Context. 7: 212536. doi: 10.7573/dic.212536
  2. Eldernawi MN, Gafri FM (2022) Unveiling of cannabidiol in the treatment of rare childhood epilepsies: Dravet and Lennox Gastaut syndromes. Mediterranean Journal of Pharmacy and Pharmaceutical Sciences. 2 (2): 18-31. doi. 10.5281/zenodo.6780458
  3. Robinson RJ (1991) Febrile convulsions. British Medical Journal. 303: 1345-1346. doi: 10.1136/bmj.303. 6814.1345
  4. Annegers JF, Hauser WA, ELveback LR, Kurland LT (1979) The risk of epilepsy following febrile convulsions. Neurology. 29 (3): 297-303.  doi: 10.1212/wnl.29.3.297
  5. Forsgren L, Sidenvall R, Blomquist HK, Heijbel J, Nystrom L (1991) Pre- and perinatal factors in febrile convulsions. Acta Paediatrica Scandinavica. 80 (2): 218-225. doi: 10.1111/j.1651-2227.1991.tb11837.x
  6. Verity CM, Ross EM, Golding J (1993) Outcome of childhood status epilepticus and lengthy febrile convulsions: findings of national cohort study. British Medical Journal. 307 (6898): 225-228. doi: 10.1136/bmj. 307.6898.225
  7. Verity CM, Greenwood R, Golding J (1998) Long-term intellectual and behavioral outcomes of children with febrile convulsions. The New England Journal of Medicine. 338: 1723-1728. doi: 10.1056/NEJM 199806113382403
  8. Verity CM (1995) Febrile convulsions. In: Epilepsy. Hopkins A, Shorvon S. 2nd Edi. 352-369. Chapman and Hall, London. ISBN: 9780412543302
  9. Cross JH (2012) Fever and fever-related epilepsies. Epilepsia. 53 (Suppl. 4): 3-8. doi: 10.1111/j.1528-1167. 2012.03608.x
  10. American Academy of Pediatrics (1980) American Academy of Pediatrics. Committee on Hospital Care. Metrication and SI units. Pediatrics. 65 (3): 659-664. PMID: 7360564.
  11. International League Against Epilepsy (2022) International League Against Epilepsy classification and definition of epilepsy syndromes with onset in childhood: Position paper by the ILAE Task Force on Nosology and Definitions. Epilepsia. 63 (6): 1398-1442. doi. 10.1111/epi.17241
  12. Kimia AA, Bachur RG, Torres A, Harper MB (2015) Febrile seizures emergency medicine perspective. Current Opinion in Pediatrics. 27 (3): 292-297. doi: 10.1097/MOP.0000000000000220
  13. American Academy of Pediatrics (2008) The use of complementary and alternative medicine in pediatrics. Pediatrics. 122 (6): 1374-1386. doi: 10.1542/peds.2008-2173
  14. Sugai K (2010) Current management of febrile seizures in Japan: an overview. Brain and Development. 32 (1): 64-70. doi: 10.1016/j.braindev.2009.09.019
  15. Lee W-L, Ong H-T (2004) A febrile seizures associated with minor infections: comparison with febrile seizures and unprovoked seizures. Pediatric Neurology. 31 (3): 157-164. doi: 10.1016/j.pediatrneurol.2004.03.022
  16. Berg AT, Shinnar S, Shapiro ED, Salomon ME, Crain EF, Hauser WA (1995) Risk factors for a first febrile seizure: a matched case-control study. Epilepsia. 36 (4): 334-341. doi: 10.1111/j.1528-1157.1995.tb01006.x
  17. Chin RFM, Neville BGR, Peckham C, Bedford H, Wade A, Scott RC (2006) Incidence, cause, and short-term outcome of convulsive status epilepticus in childhood: prospective population-based study. The Lancet. 368 (9531): 222-229. doi: 10.1016/S0140-6736(06)69043-0
  18. Millichap JG (2008) Risk of mortality in children with febrile seizures. Pediatric Neurology Briefs. 22 (9): 68-69. doi: 10.15844/pedneurbriefs-22-9-5
  19. Audenaert D, Broeckhoven CV, Jonghe PD (2006) Genes and loci involved in febrile seizures and related epilepsy syndromes. Human mutation. 27 (5): 391-401. doi: 10.1002/humu.20279
  20. D Sapir, Y Leitner, S Harel, U Kramer (2000) Unprovoked seizures after complex febrile convulsions. Brian and development. 22 (8): 484-486. doi: 10.1016/s0387-7604(00)00187-x
  21. Chung S (2014) Febrile seizures. Korean Journal Pediatrics. 57 (9): 384-395. doi: 10.3345/kjp.2014.57.9.384
  22. Vestergaard M, Pedersen MG, Ostergaard JR, Pedersen CB, Olsen J, Christensen J (2008) Death in children with febrile seizures: a population-based cohort study Lancet. 372 (9637): 457-463. doi: 10.1016/S0140-6736 (08)61198-8
  23. Shrestha D, Dhakal AK, Shakya H, A Shakya A, Shah SC, Mehata S (2014) Clinical characteristics of children with febrile seizure. Journal of Nepal Health Research Council. 12 (28): 162-166. PMID: 26032052.
  24. Laino D, Mencaroni E, Esposito S (2018) Management of Pediatric Febrile Seizures. International Journal of Environmental Research and Public Health. 15 (10): 2232. doi: 10.3390/ijerph15102232
  25. Shah SS, Alpern ER, Zwerling L, Reid JR, McGowan KL, Bell LM (2022) Low risk of bacteremia in children with febrile seizures. Pediatric and Adolescent Medicine. 156 (5): 469-472. doi: 10.1001/archpedi.156.5.469
  26.  Mohsenipour R, Saidi M, P Rahmani P (2017) Assessment of causative factors of febrile seizure related to a group of children in Iran. Biomed Research. 28 (4): 1548-1552. doi: Nil.
  27. Adhikari S, Sathian B, Koirala DP, Rao KS (2013) Profile of children admitted with seizures in a tertiary care hospital of Western Nepal. BMC Pediatrics. 13: 43. doi: 10.1186/1471-2431-13-43
  28. Mohammed HS, Aboul Ezz HS, Sayed HM, Ali MA (2017) Electroencephalographic and biochemical long-lasting abnormalities in animal model of febrile seizure. Biochimica et Biophysica Acta: Molecular Basis of Disease. 1863 (9): 2120-2125. doi: 10.1016/j.bbadis.2017.05.024
  29. Mahmood KT, Fareed T, Tabbasum R (2011) Management of febrile seizures in children. Journal of Biomedical Sciences and Research. 3 (1): 353-357. doi: Nil.

Submitted date:
03/14/2023

Reviewed date:
04/20/2023

Accepted date:
04/25/2023

Publication date:
07/20/2023

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