30DEC

Libyan International Conference for Health Sciences

The First Libyan International Conference for Health Sciences (2024): Open University, Tripoli, Libya
Mediterranean Journal of Pharmacy and Pharmaceutical Sciences
https://ppj.org.ly/article/doi/10.5281/zenodo.8136836

Mediterranean Journal of Pharmacy and Pharmaceutical Sciences

Original article

Quality control of selected cosmetics marketed in Libya for traces of toxic heavy metals: urgent need of guidelines harmonization

Omar A. Rbeida, Suaad M. Abuskhona, Shahrazad A. Eteer, Asma O. Jebril

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Abstract

Heavy metals and trace elements such as lead (Pb), mercury (Hg), cadmium (Cd), arsenic (Ar), nickel (Ni), Chromium (Cr), cobalt (Co), copper (Cu), mercury (Mg), iron (Fe) and aluminum (Al) are detected in various types of herbal cosmetics. Heavy metals and elements can accumulate at high concentrations causing serious risks to human health when consumed. In this study, the levels of potential heavy metals of Pb, Ar, Cd, and Ni were quantitatively determined using atomic absorption spectroscopy. Samples of Henna leaves, Henna paste, Khol stones and baby Talcum powder were collected randomly from different public markets in Tripoli City, Libya. The results were evaluated by using different international guidelines, US-FDA, EU regulation, German (BVL), World Health Organization (WHO) and Canadian Guidelines. Because of controversial global guidelines, the study urgent the ultimate need for setting up harmonized minimum levels of heavy metals in cosmetics that could be applicable worldwide. Generally, the presence of a higher concentration of some of the studied heavy metals was observed, and the effect of these heavy metals at higher levels will be more harmful to consumer health after prolonged usage. In conclusion, nationally, the need for developing and updating the national specification for cosmetics by the Libyan National Centre for Standardization and Metrology (LNCSM) to protect consumers from more catastrophic cosmetic hazards is urgently required.

Keywords

Cosmetics, hazards, potential heavy metal, post-marketing, Libya

References

  1. Bechtold TH, Mussak R (2009) Handbook of natural colorants. John Wiley & Sons, Ltd. Amsterdam. ISBN: 9780470744970. doi: 10.1002/9780470744970
  2. Roa N, Pathriba S (1998) Cosmetics and personal care products I. Elsevier Inc., 380 -382. doi: Nil.
  3. Muheyuddeen G, Divy SR, Gautam SK, Sujeet Kumar Gupta SK (2023) Lawsonia inermis Linnaeus: pharmacological peculiarity and modern progression. Research Journal of Pharmacognosy and Phytochemistry. 15 (1): 63-66. doi: 10.52711/0975-4385.2023.00010
  4. Mahmood ZA, Zoha SMS, Usmanghani K, Hasan MM, Ali O, Jahan S, Saeed A, Zaihd R, Zubier M (2009) Kohl (surma): retrospect and prospect. Pakistan Journal of Pharmaceutical Sciences. 22 (1): 107-122. PMID: 19168431
  5. Bird T, Steffen JE, Tran TH, Egilman DS (2021) A review of the talc industry’s influence on Federal Regulation and Scientific Standards for Asbestos in talc. New Solutions. Journal of Environmental and Occupational Health Policy. 31 (2): 152-169. doi: 10.1177/1048291121996645
  6. Gondal MA, Dastageer MA, Naqvi AA, Isab AA, Maganda YW (2012) Detection of toxic metals (lead and chromium) in talcum powder using laser induced breakdown spectroscopy. Applied Optics. 51 (30): 7395-7401. doi: 10.1364/AO.51.007395
  7. Sukender K, Jaspreet S, Sneha D, Munish G (2012) AAS estimation of heavy metals and trace elements in Indian herbal cosmetic preparations. Research Journal of Chemical Sciences. 2 (3): 46-51. Corpus ID: 101579506
  8. Prasad MN, Shanker AK (2008) Mode of action and toxicity of trace elements. Public Health Reports. 38: 1882-1912. doi: 10.1002/9780470370124.ch21
  9. Environmental Defense, Ontario, Canada, 2011. http://www.greenbiz.com/default/files/HeavyMetalHazard.
  10. Tan SW, Meiller JC, Mahaffey KR (2009) The endocrine effects of mercury in humans and wildlife. Critical Review of Toxicology. 39 (3): 228-269. doi: 10.1080/10408440802233259
  11. Liu D, Shi Q, Liu C, Sun Q, Zeng X (2023) Effects of endocrine-disrupters heavy metals on human healths. Toxics. 11 (4): 322. doi: 10.3390/toxics11040322
  12. Filon FL, D’Agostin F, Crosera M, Adami G, Bovenzi M, Maina G (2009) In vitro absorption of metal powders through intact and damaged human skin. Toxicology in Vitro. 23 (4): 574-579. doi: 10.1016/j.tiv.2009.01.015
  13. Al-Ashbanab RM, Aslama M, Shahb AH (2004) Kohl (surma): a toxic traditional eye cosmetic study in Saudi Arabia. Public Health. 118 (4): 292-298. doi: 10.1016/j.puhe.2003.05.001
  14. Stauber TM, Florence BL, Gulson LS, Dale S (1994) Percutaneous absorption of inorganic lead compounds. The Science of The Total Environment. 145 (1-2): 55-70. doi: 10.1016/0048-9697(94)90297-6
  15. Iavicoli I, Fontana L, Bergamaschi A (2009) The effects of metals as endocrine disruptors. Journal of Toxicology and Environmental Health. Critical Reviews. 12 (3): 206-223. doi: 10.1080/10937400902902062
  16. Al-Saleh I, Al-Enazi S, Shinwari N (2009) Assessment of lead in cosmetic products. Regulatory Toxicology and Pharmacology. 54 (2): 105-113. doi: 10.1016/j.yrtph.2009.02.005
  17. Ayenimo JG, Yusuf AM, Adekunle AS, Makinde OW (2010) Heavy metal exposure from personal care products. Bulletin of Environmental Contamination and Toxicology. 84 (1): 8-14. doi: 10.1007/s00128-009-9867-5
  18. Thyssen JP, Menné T (2014) Metal allergy: A review on exposures, penetration, genetics, prevalence, and clinical implications. Chemical Heavy Metals in Cosmetics. doi: 10.5772/intechopen.102406
  19. Juliano C, Magrini GA (2017) Cosmetic ingredients as emerging pollutants of environmental and health concern. A mini-review. Cosmetics. 4 (2): 11. doi: 10.3390/cosmetics4020011
  20. Bocca B, Pino A, Alimonti A, Forte G (2014) Toxic metals contained in cosmetics. Regulatory Toxicology and Pharmacology. 68 (3): 447-467. doi: 10.1016/j.yrtph.2014.02.003
  21. Regulation (EC) No 1223/2009 of the European Parliament and the Council on Cosmetics (recast) (Text with EEA relevance) Official Journal of the European Union (30 November 2009).
  22. German Federal Office of Consumer Protection and Food Safety (BVL) (2009).
  23. The International Federation of Societies of Cosmetic Chemists (1992) Monograph number 2: The Fundamentals of Stability Testing, Michelle Press, IFSCC.
  24. Rahil SYS, Elshara IA, Ahmida NHS, Ahmida MHS (2016) Determination of some heavy metals in cosmetic products collected from Benghazi, Libya market during 2016. Libyan International Medical University Journal. 4 (1): 10-17. doi: 10.1055/s-00053243
  25. Orish EO, Jonathan JO (2013) Metal concentrations in cosmetics commonly used in Nigeria. The Scientific World Journal. Article ID: 959637. 7. doi: 10.1155/2013/959637
  26. Massadyikeh AM, El‑Khateeb MY, Ibrahim SM (2017) Evaluation of Cd, Cr, Cu, Ni, and Pb in selected cosmetic products from Jordanian, Sudanese, and Syrian markets. Public Health. 149: 130-137. doi: 10.1016/j. puhe.2017.03.015

Submitted date:
05/15/2023

Reviewed date:
07/04/2023

Accepted date:
07/11/2023

Publication date:
07/12/2023

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